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Neurogenesis and Regeneration of Nervous Tissue

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...

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Related Experiment Video

Updated: Oct 11, 2025

Author Spotlight: Using Zebrafish to Explore Microglia Migration During Brain Development

Author Spotlight: Using Zebrafish to Explore Microglia Migration During Brain Development

Published on: May 17, 2024

The origin and repopulation of microglia.

Lijuan Zhang¹, Yue Cao¹, Xin Zhang¹

¹Department of Neurosurgery, Huashan Hospital, Institute for Translational Brain Research, State Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China.

Developmental Neurobiology

|December 7, 2021

Summary

Microglia, the brain's immune cells, are crucial for development and disease. Recent research illuminates their mysterious birth and regeneration, offering potential new therapies for brain disorders.

Keywords:

immune cells inflammatory diseases microglia origin regeneration

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Last Updated: Oct 11, 2025

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Published on: April 13, 2017

Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates

Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates

Published on: January 30, 2014

Area of Science:

Neuroscience
Immunology
Cell Biology

Background:

Microglia are key immune cells within the central nervous system.
Their roles in neurodevelopment, injury, and neuropsychiatric disorders are increasingly recognized.
Microglia exhibit dynamic life cycles including birth, death, and regeneration.

Purpose of the Study:

To review recent studies on the origin and regeneration of microglia.
To explore the enigmatic processes of microglial birth and repopulation.
To highlight the therapeutic potential of modulating microglial development.

Main Methods:

Literature review of recent scientific studies.
Synthesis of current understanding regarding microglial ontogeny and dynamics.
Analysis of emerging insights into microglial regeneration.

Main Results:

Recent studies offer new perspectives on microglial origin and regeneration.
The processes of microglial birth and repopulation are complex and not fully understood.
Modulating microglial development presents potential therapeutic avenues.

Conclusions:

Understanding microglial regeneration is critical for advancing neuroscience.
Targeting microglial development may offer novel strategies for treating brain diseases.
Further research into microglial dynamics can unlock new therapeutic opportunities for neuroinflammation.