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A longitudinal population-based study of predictors of mortality from bloodstream infections in Calgary, Alberta,

Deirdre Church1,2,3, Ranjani Somayaji2,4,5, Jeannine Viczko1,3

  • 1Department of Pathology & Laboratory Medicine, Calgary, AB T2N 4N1, Canada.

Future Microbiology
|December 7, 2021
PubMed

Insights

Bloodstream infections (BSI) have a high mortality rate. Patient survival depends on their health status and the specific pathogen causing the infection.

Area of Science:

  • Infectious Diseases
  • Epidemiology
  • Clinical Microbiology

Background:

  • Bloodstream infections (BSI) represent a significant global health challenge.
  • Understanding mortality predictors is crucial for effective patient management and public health strategies.
  • Nine major pathogens account for a substantial proportion of BSI cases.

Purpose of the Study:

  • To identify predictors of mortality in patients with bloodstream infections (BSI).
  • To analyze mortality trends over a 7-year period.
  • To investigate the influence of specific pathogens on BSI outcomes.

Main Methods:

  • A population-based surveillance cohort study was conducted.
  • Adult and pediatric patients with an initial BSI episode in the Calgary Zone were included.
  • Data were collected over a 7-year period.

Main Results:

  • The 1-year mortality rate for BSI was 29.2% among 9524 patients.
  • Annual BSI incidence increased to 119.7 per 100,000 persons by 2016.
  • Patient age, comorbidity burden, and the specific infecting organism were significant predictors of mortality.
  • Time to positivity for blood cultures did not correlate with overall mortality.

Conclusions:

  • Bloodstream infections are associated with high mortality.
  • Patient survival is influenced by pre-existing health conditions and the causative pathogen.
  • Further research into pathogen-specific virulence and host-pathogen interactions is warranted.

Keywords:
bloodstream infectionsmortalitypathogenpopulation basedpredictorstime to positivity

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