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Related Experiment Videos

Epidermal growth factor: effect on circulating thyroid hormone levels in sheep.

J M Corcoran, M J Waters, C J Eastman

    Endocrinology
    |July 1, 1986
    PubMed
    Summary

    Epidermal growth factor (EGF) infusion significantly lowered circulating thyroid hormones (T4 and T3) in ewes. EGF also impacted thyroid hormone metabolism, suggesting a dual inhibitory role.

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    Area of Science:

    • Endocrinology
    • Molecular Biology
    • Animal Physiology

    Background:

    • Thyroid hormones regulate metabolism.
    • Epidermal growth factor (EGF) influences various cellular processes.
    • Previous studies suggested interactions between EGF and thyroid hormones.

    Purpose of the Study:

    • To investigate the interaction between EGF and thyroid hormones in vivo.
    • To determine the effect of EGF infusion on circulating thyroid hormone levels and metabolism.

    Main Methods:

    • Infusion of mouse EGF into merino ewes for 24 hours.
    • Measurement of circulating thyroxine (T4), triiodothyronine (T3), thyroid-stimulating hormone (TSH), reverse triiodothyronine (rT3), and 3,3'-diiodothyronine levels.
    • Comparison with saline-infused control ewes.

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    Main Results:

    • EGF infusion caused a profound depression of T4 and T3 levels to less than 20% of control values.
    • Plasma TSH concentrations remained unchanged during the initial 8 hours of infusion.
    • Serum rT3 and 3,3'-diiodothyronine showed a transient 6-fold increase.

    Conclusions:

    • EGF exerts a dual inhibitory effect on thyroid hormone secretion and peripheral metabolism.
    • EGF does not appear to suppress the hypothalamic-pituitary axis directly.
    • Findings suggest a complex interplay between EGF and the thyroid hormone system.