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Related Concept Videos

Tissue Transplantation01:24

Tissue Transplantation

570
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
570
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

74
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
74
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

89
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
89

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Related Experiment Video

Updated: Oct 11, 2025

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
18:48

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Towards tolerance in liver transplantation.

L Toti1, T M Manzia2, B Sensi2

  • 1Hepato-Pancreato-Biliary and Transplant Unit, Fondazione Policlinico Tor Vergata, Rome, Italy.

Best Practice & Research. Clinical Gastroenterology
|December 7, 2021
PubMed
Summary

Liver transplantation patients may safely stop immunosuppression due to the liver's natural tolerance. This could reduce severe side effects associated with long-term immune suppression therapy.

Keywords:
ImmunosuppressionLiver transplantationOperational tolerance

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Area of Science:

  • Immunology
  • Transplantation Medicine
  • Hepatology

Background:

  • Long-term immunosuppression is standard after liver transplantation to prevent graft rejection.
  • However, this therapy carries significant risks, including infections, cardiovascular issues, and malignancies.

Purpose of the Study:

  • To explore the potential for safe withdrawal of immunosuppression in liver transplant recipients.
  • To investigate the liver's inherent tolerogenic properties in the context of transplantation.

Main Methods:

  • Review of current literature on immunosuppression and liver transplantation.
  • Analysis of data regarding liver graft tolerogenicity.
  • Evaluation of patient outcomes after immunosuppression withdrawal in select cases.

Main Results:

  • The liver is recognized as a privileged organ with significant tolerogenic capacity.
  • A substantial proportion (up to 60%) of carefully selected liver transplant patients may be candidates for immunosuppression cessation.

Conclusions:

  • Liver transplantation offers a unique opportunity to achieve operational tolerance, potentially eliminating the need for lifelong immunosuppression.
  • Withdrawal of immunosuppression in selected liver transplant recipients could significantly improve long-term outcomes and reduce treatment-related complications.