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Updated: Oct 10, 2025

Method for Measuring the Activity of Deubiquitinating Enzymes in Cell Lines and Tissue Samples
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Method for Measuring the Activity of Deubiquitinating Enzymes in Cell Lines and Tissue Samples

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Deubiquitinating enzyme OTUB1 in immunity and cancer: Good player or bad actor?

Yihao Liao1, Mengyue Yang2, Keke Wang1

  • 1Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin, 300211, China.

Cancer Letters
|December 7, 2021
PubMed

Insights

OTU deubiquitinase domain-containing protein 1 (OTUB1) is crucial in DNA repair and immune responses. Targeting OTUB1 shows potential for treating cancers and immune disorders by modulating immune cell activity.

Area of Science:

  • Biochemistry
  • Immunology
  • Oncology

Background:

  • OTU deubiquitinase domain-containing protein 1 (OTUB1) is a key member of the deubiquitinase OTU superfamily.
  • OTUB1 regulates critical physiological processes including DNA damage repair and cytokine secretion.
  • Emerging research highlights OTUB1's role in cancer development and its intricate connection with the immune system.

Purpose of the Study:

  • To provide a comprehensive overview of OTUB1's function and regulatory mechanisms.
  • To explore the implications of OTUB1 in immune responses and cancer progression.
  • To evaluate OTUB1 as a potential therapeutic target for cancer and immune-related diseases.

Main Methods:

  • Literature review of experimental evidence on OTUB1.
  • Analysis of OTUB1's deubiquitinating and protein-stabilizing activities.
  • Examination of OTUB1's impact on immune cell function and cancer pathways.

Main Results:

  • OTUB1 influences NK/CD8 T cell activation, autoimmune diseases, and immune evasion via PD-L1.
  • OTUB1 plays a role in immune responses to viral/bacterial infections and cancer development.
  • Deubiquitinating and stabilizing target proteins are key mechanisms for OTUB1's action.

Conclusions:

  • Regulating OTUB1 levels can balance immune response and defense mechanisms.
  • Targeting OTUB1 presents a promising strategy to inhibit cancer progression.
  • OTUB1 is identified as a feasible therapeutic target for various cancers and immune disorders.
Keywords:
CancerImmunityInflammationOTUB1Treatment

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