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Combined Administration of Andrographolide and Angiotensin- (1-7) Synergically Increases the Muscle Function and
Johanna Abrigo1,2,3, Felipe Simon2,4,5, Daniel Cabrera6,7
1Laboratory of Muscle Pathology, Fragility and Aging, Department of Biological Sciences, Faculty of Life Sciences, Universidad Andres Bello. Santiago, Chile.
Background:
Sarcopenia is a progressive and generalized skeletal muscle disorder characterized by muscle weakness, loss of muscle mass, and decline in the capacity of force generation. Aging can cause sarcopenia. Several therapeutic strategies have been evaluated to prevent or alleviate this disorder. One of them is angiotensin 1-7 [Ang-(1-7)], an anti-atrophic peptide for skeletal muscles that regulates decreased muscle mass for several causes, including aging. Another regulator of muscle mass and function is andrographolide, a bicyclic diterpenoid lactone that decreases the nuclear factor kappa B (NF-κB) signaling and attenuates the severity of some muscle diseases.
Objective:
Evaluate the effect of combined administration of Ang-(1-7) with andrographolide on the physical performance, muscle strength, and fiber´s diameter in a murine model of sarcopenia by aging.
Methods:
Aged male mice of the C57BL/6J strain were treated with Andrographolide, Ang-(1-7), or combined for three months. The physical performance, muscle strength, and fiber´s diameter were measured.
Results:
The results showed that aged mice (24 months old) treated with Ang-(1-7) or Andrographolide improved their performance on a treadmill test, muscle strength, and their fiber´s diameter compared to aged mice without treatment. The combined administration of Ang-(1-7) with andrographolide to aged mice has an enhanced synergically effect on physical performance, muscle strength, and fiber´s diameter.
Conclusion:
Our results indicated that in aged mice, the effects of andrographolide and Ang-(1-7) on muscle function, strength, and fiber´s diameter are potentiated.
Insights
Combined treatment with angiotensin 1-7 [Ang-(1-7)] and andrographolide enhances muscle strength and physical performance in aged mice. This synergistic effect combats age-related sarcopenia, improving muscle mass and function.
Area of Science:
- Gerontology and Muscle Physiology
- Pharmacology and Therapeutics
Background:
- Sarcopenia is a progressive muscle disorder linked to aging, characterized by reduced muscle mass and strength.
- Angiotensin 1-7 [Ang-(1-7)] and andrographolide are known regulators of skeletal muscle mass and function.
- Ang-(1-7) acts as an anti-atrophic peptide, while andrographolide modulates NF-κB signaling.
Purpose of the Study:
- To investigate the combined therapeutic effects of Ang-(1-7) and andrographolide on age-related sarcopenia.
- To evaluate the impact of this combination on physical performance, muscle strength, and muscle fiber diameter in aged mice.
Main Methods:
- Aged male C57BL/6J mice were administered Andrographolide, Ang-(1-7), or a combination therapy over three months.
- Key physiological and morphological parameters including physical performance, muscle strength, and muscle fiber diameter were assessed.
Main Results:
- Both Ang-(1-7) and andrographolide individually improved treadmill performance, muscle strength, and fiber diameter in aged mice.
- The combined administration of Ang-(1-7) and andrographolide demonstrated a synergistic enhancement of these parameters.
Conclusions:
- The combination of andrographolide and Ang-(1-7) potentiates beneficial effects on muscle function and strength in aged mice.
- This synergistic action offers a promising therapeutic strategy for mitigating age-related sarcopenia.
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