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Complicated Trichosporon asahii mastoiditis in immunocompetent child

Miral Al Momani1, Dawood H Yusef2, Du'a Hamasha2

  • 1Department of Pediatrics and Neonatology, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan. maalmomani3@just.edu.jo.

BMC Infectious Diseases
|December 8, 2021
PubMed
Abstract

Insights

This case study highlights Trichosporon asahii mastoiditis in an immunocompetent child. Early diagnosis and voriconazole treatment were crucial for successful recovery, even with complications like transverse sinus thrombosis.

Area of Science:

  • Mycology
  • Infectious Diseases
  • Pediatrics

Background:

  • Trichosporon asahii is an opportunistic fungus typically affecting immunosuppressed individuals.
  • Infections in immunocompetent hosts, especially children, are rare and challenging.
  • High mortality rates associated with Trichosporon asahii infections persist despite treatment.

Observation:

  • A 21-month-old immunocompetent girl presented with prolonged fever and ear discharge.
  • Initial antimicrobial treatments were ineffective.
  • Trichosporon asahii was repeatedly isolated from ear discharge.

Findings:

  • The patient developed mastoiditis complicated by transverse sinus thrombosis.
  • Treatment with voriconazole led to significant clinical improvement within 48 hours.
  • Successful management of a rare fungal infection in a healthy child.

Implications:

  • Highlights the need for high clinical and microbiological suspicion for Trichosporon infections.
  • Demonstrates that Trichosporon asahii can infect immunocompetent individuals.
  • Emphasizes the importance of early pediatric infectious disease evaluation and intervention.
Keywords:
Case reportChildrenDrug resistanceFungalMastoiditisTrichosporon asahii

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