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Updated: Oct 10, 2025

In Vivo Infection with Leishmania amazonensis to Evaluate Parasite Virulence in Mice
Published on: February 20, 2020
Amputation of a type II diabetic patient with cutaneous leishmaniasis due to Leishmania major
Arezki Izri1,2, Amina Bendjaballah-Laliam3, Denis Sereno4,5
1Parasitology-Mycology Department, Avicenne Hospital, AP-HP, 125, Route de Stalingrad, Bobigny Cedex, 93009, France.
Background:
Leishmaniases are neglected tropical diseases of public health concern in Algeria. The immunocompromised patients with HIV, autoimmune diseases, or chronic alcohol abuse are at a higher risk of leishmaniasis. Herein, we present the case of an immunocompetent diabetic patient infected by Leishmania major, leading to life-threatening consequences.
Case Presentation:
An Algerian diabetic patient developed a cutaneous lesion with large polymorphous inflamed granuloma and pyoderma gangrenosum in the left foot, following L. major infection. A delayed follow-up led to a treatment failure, resulting in the amputation.
Conclusions:
This report highlights the absence of timely treatment of Leishmania infection as a life-threatening point among high-risk diabetic patients. Clinicians should be aware of this parasitosis leading to severe complications in diabetic patients.
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