Related Experiment Video
Updated: Oct 10, 2025
08:41
Modeling Chemotherapy Resistant Leukemia In Vitro
Published on: February 9, 2016
9.2K
Bone damage after chemotherapy for lymphoma: a real-world experience
S Mancuso1, Dalila Scaturro2, M Santoro1
1Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), Hematology Unit, University of Palermo, Palermo, Italy.
BMC Musculoskeletal Disorders
|December 8, 2021
Summary
Lymphoma survivors experience significant bone loss and fractures, with over 50% developing osteoporosis. Early prevention strategies are crucial to mitigate these long-term skeletal complications and improve quality of life.
Area of Science:
- Oncology
- Endocrinology
- Bone Metabolism
Background:
- Lymphoma treatments, including chemotherapy and steroids, can negatively impact patient quality of life.
- Long-term complications such as bone loss and fragility fractures are significant concerns for lymphoma survivors.
Purpose of the Study:
- To investigate skeletal complications in lymphoma patients with complete response to therapy.
- To correlate bone disease markers with clinical and biological variables.
Main Methods:
- Cross-sectional observational study of lymphoma patients in complete response for at least one year.
- Evaluated bone health using blood tests, imaging, and quality of life questionnaires (SARC-F, mini-OQLQ).
Main Results:
- 50% of patients had osteoporosis; 65.5% had vertebral fractures.
- Hypovitaminosis D and elevated parathyroid hormone (PTH) were common.
- High PTH levels were significantly associated with prior lymphoma treatment.
Conclusions:
- Personalized chemotherapy regimens may reduce late bone effects.
- Early bone health prevention programs are recommended before treatment initiation.
- Both elderly and young lymphoma patients could benefit from these interventions.
Related Concept Videos
01:22Bone Marrow Sampling and Transplants
556
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
556
01:29Bone Disorders
4.2K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
4.2K
01:21Stem Cell Therapy for Tissue Regeneration
4.3K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.3K
01:29Blood and Nerve Supply to the Bones
12.3K
Bones are dynamic organs that require a rich supply of oxygen and nutrients. Around 5% to 10% of the cardiac output supplies blood to the bones. A typical long bone has three main sources: the nutrient artery, the metaphyseal and epiphyseal arteries, and the periosteal arteries.
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
12.3K
01:27Fractures: Bone Repair
3.9K
Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
3.9K