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Basal Lamina are the Specialized Form of ECM01:03

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Basal lamina changes in neurodegenerative disorders.

Benjamin Nguyen1, Gregory Bix2,3, Yao Yao4,5

  • 1Department of Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, GA, USA.

Molecular Neurodegeneration
|December 8, 2021
PubMed
Summary

The basal lamina (BL) plays a crucial role in maintaining blood-brain barrier (BBB) integrity and meningeal lymphatic function. Understanding BL changes in neurodegenerative diseases like Alzheimer's and Parkinson's is vital for future therapies.

Keywords:
Basal laminaBlood-Brain BarrierLamininNeurodegenerative disordersPerlecan

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Area of Science:

  • Neuroscience
  • Cell Biology
  • Pathology

Background:

  • Neurodegenerative disorders involve central nervous system (CNS) degeneration, characterized by blood-brain barrier (BBB) breakdown and protein aggregation.
  • The basal lamina (BL), a component of the BBB, has largely unknown roles in BBB maintenance and function.
  • The BL's location in the perivascular space suggests a role in regulating protein clearance via the meningeal lymphatic/glymphatic system.

Purpose of the Study:

  • To review the changes in the basal lamina (BL) and its components during aging and in neurodegenerative disorders.
  • To explore the functional significance of BL alterations in the pathogenesis and progression of neurodegenerative diseases.
  • To identify potential therapeutic targets related to BL dysfunction.

Main Methods:

  • Review of existing literature on the basal lamina (BL) and its role in the CNS.
  • Analysis of studies investigating BL changes in aging and neurodegenerative conditions (Alzheimer's disease, Parkinson's disease, ALS) in rodents and humans.
  • Discussion of the functional implications of BL alterations and potential therapeutic strategies.

Main Results:

  • Recent studies indicate the basal lamina (BL) actively regulates BBB integrity and meningeal lymphatic/glymphatic function.
  • Alterations in the BL and its components are observed during aging and in neurodegenerative disorders.
  • The BL's role in neurodegenerative disorders is increasingly recognized, suggesting its importance in disease pathogenesis.

Conclusions:

  • Understanding basal lamina (BL) changes is critical for filling knowledge gaps in neurodegenerative disorder research.
  • The review aims to clarify the complex relationship between the BL and neurodegenerative disorders.
  • Further research into the BL's role may stimulate new hypotheses and therapeutic approaches for neurodegenerative diseases.