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Related Experiment Video

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Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression

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[Ketamine Augmented Psychotherapy (KAP) in mood disorder: User guide].

H Bottemanne¹, A Baldacci², C Muller²

¹Paris Brain Institute - Institut du cerveau (ICM), Sorbonne University/CNRS/Inserm, UMR 7225/UMRS 1127, Paris, France; Sorbonne University, Department of Philosophy, UMR 8011, CNRS, Paris, France; Department of Psychiatry, Pitié-Salpêtrière Hospital, DMU Neuroscience, Sorbonne University, AP-HP, Paris, France.

|December 8, 2021

Summary

Ketamine combined with psychotherapy offers a novel approach to treating depression. This Ketamine Augmented Psychotherapy (KAP) protocol integrates dissociative effects and brain plasticity for enhanced therapeutic outcomes.

Keywords:

Antidepressant Antidépresseur Augmented psychotherapy Belief Belief updating Codage prédictif Croyance Dissociation Ketamine Ketamine assisted psychotherapy Kétamine Mise à jour des croyances Predictive coding Psychedelic Psychothérapie assistée par kétamine Psychothérapie augmentée Psychédélique

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Area of Science:

Neuroscience
Psychiatry
Pharmacology

Background:

Ketamine is a fast-acting antidepressant targeting NMDA receptors.
Clinical use often omits psychotherapy despite potential benefits.
Dissociative effects and synaptogenesis may enhance cognitive therapies.

Purpose of the Study:

Propose a practical protocol for Ketamine Augmented Psychotherapy (KAP).
Synthesize current literature and clinical experience for KAP.
Detail clinical practice guidelines for KAP.

Main Methods:

Literature synthesis and clinical experience compilation.
Development of a four-step KAP protocol: preparation, administration, integration, prolongation.
Discussion of limits and future prospects of KAP.

Main Results:

A structured protocol for integrating ketamine with psychotherapy is presented.
The protocol leverages ketamine's dissociative and synaptogenic effects.
Guidelines for clinical application are detailed.

Conclusions:

Ketamine Augmented Psychotherapy (KAP) offers a promising combination for mood disorder management.
The proposed protocol provides a framework for safe and effective KAP implementation.
Further research is needed to explore KAP's full potential and limitations.