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[Ketamine Augmented Psychotherapy (KAP) in mood disorder: User guide]
H Bottemanne1, A Baldacci2, C Muller2
1Paris Brain Institute - Institut du cerveau (ICM), Sorbonne University/CNRS/Inserm, UMR 7225/UMRS 1127, Paris, France; Sorbonne University, Department of Philosophy, UMR 8011, CNRS, Paris, France; Department of Psychiatry, Pitié-Salpêtrière Hospital, DMU Neuroscience, Sorbonne University, AP-HP, Paris, France.
L'Encephale
|December 8, 2021
Summary
Ketamine combined with psychotherapy offers a novel approach to treating depression. This Ketamine Augmented Psychotherapy (KAP) protocol integrates dissociative effects and brain plasticity for enhanced therapeutic outcomes.
Area of Science:
- Neuroscience
- Psychiatry
- Pharmacology
Background:
- Ketamine is a fast-acting antidepressant targeting NMDA receptors.
- Clinical use often omits psychotherapy despite potential benefits.
- Dissociative effects and synaptogenesis may enhance cognitive therapies.
Purpose of the Study:
- Propose a practical protocol for Ketamine Augmented Psychotherapy (KAP).
- Synthesize current literature and clinical experience for KAP.
- Detail clinical practice guidelines for KAP.
Main Methods:
- Literature synthesis and clinical experience compilation.
- Development of a four-step KAP protocol: preparation, administration, integration, prolongation.
- Discussion of limits and future prospects of KAP.
Main Results:
- A structured protocol for integrating ketamine with psychotherapy is presented.
- The protocol leverages ketamine's dissociative and synaptogenic effects.
- Guidelines for clinical application are detailed.
Conclusions:
- Ketamine Augmented Psychotherapy (KAP) offers a promising combination for mood disorder management.
- The proposed protocol provides a framework for safe and effective KAP implementation.
- Further research is needed to explore KAP's full potential and limitations.
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