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Updated: Oct 10, 2025

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Direct Force Measurements of Subcellular Mechanics in Confinement using Optical Tweezers
Published on: August 31, 2021
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Force measurement goes to femto-Newton sensitivity of single microscopic particle
Xiaohe Zhang1,2, Bing Gu1, Cheng-Wei Qiu3
1Advanced Photonics Center, Southeast University, Nanjing, 210096, China.
Light, Science & Applications
|December 8, 2021
Abstract:
Highly sensitive force measurements of a single microscopic particle with femto-Newton sensitivity have remained elusive owing to the existence of fundamental thermal noise. Now, researchers have proposed an optically controlled hydrodynamic manipulation method, which can measure the weak force of a single microscopic particle with femto-Newton sensitivity.

