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Updated: Oct 10, 2025
Body Composition and Metabolic Caging Analysis in High Fat Fed Mice
Published on: May 24, 2018
Analysis of Serum Metabolomics in Obese Mice Induced by High-Fat Diet
Li Bao1,2, Chunjing Yang1,2, Zhengyuan Shi1,2
1Department of Pharmacy, Beijing Shijitan Hospital, Capital Medical University, Beijing, People's Republic of China.
Background:
Obesity is a public health problem all over the world, and dietary habits are considered one of the important reasons.
Methods:
In this study, serum metabolites of mice fed a normal or high-fat diet (HFD) were analyzed using UPLC-QTOF-MS.
Results:
A significant increase in body weight was noted in HFD mice. The HFD and control groups were significantly different from each other on OPLS-DA scores. The major metabolites contributing to obesity were lipid metabolites (phosphatidylcholines, phosphatidylethanolamine, and lysophosphatidylcholines). In addition, this study revealed that glycerophospholipid metabolism, α-linolenic acid metabolism, and linoleic acid metabolism were related to obesity and obesity-associated diseases.
Conclusion:
These results can be used to better understand obesity and assess its risk, which will provide new ideas for treatment.
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