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Related Concept Videos

Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

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Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
245
Drugs for Treatment of Ulcerative Colitis in IBD01:29

Drugs for Treatment of Ulcerative Colitis in IBD

264
Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
264
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents01:29

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

284
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
284
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

451
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
451
Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

230
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
230
Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids01:21

Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids

236
Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
236

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Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis
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Indeterminate Colitis - Update on Treatment Options.

Niranjani Venkateswaran1, Scott Weismiller1, Kofi Clarke2

  • 1Division of General Internal Medicine, Department of Medicine, Pennsylvania State University College of Medicine, Hershey, PA, USA.

Journal of Inflammation Research
|December 8, 2021
PubMed
Summary
This summary is machine-generated.

Indeterminate colitis (IC), a subset of inflammatory bowel disease (IBD), often evolves to a definitive diagnosis. Treatment typically mirrors ulcerative colitis (UC) or Crohn

Keywords:
Crohn’s diseaseileal pouch–anal anastomosisindeterminate colitismedical treatmenttotal proctocolectomyulcerative colitis

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Area of Science:

  • Gastroenterology
  • Pathology
  • Internal Medicine

Background:

  • Indeterminate colitis (IC) affects 5-15% of inflammatory bowel disease (IBD) patients.
  • Distinguishing IC from ulcerative colitis (UC) and Crohn's disease (CD) can be challenging on biopsy.
  • IC is also known as inflammatory bowel disease unclassified (IBDU).

Purpose of the Study:

  • To review the limited literature on medical and surgical treatments for IC.
  • To highlight the lack of dedicated controlled trials for IC treatment.
  • To discuss the clinical evolution and management strategies for IC.

Main Methods:

  • Literature review of existing studies on IC treatment.
  • Analysis of clinical course and diagnostic challenges in IC.
  • Comparison of treatment approaches for IC versus UC and CD.

Main Results:

  • Most IC patients eventually receive a UC or CD diagnosis.
  • Medical treatment for IC often follows UC protocols, based on severity.
  • Surgical options like IPAA have similar complication rates in IC and UC patients.

Conclusions:

  • IC management relies on extrapolating data from UC and CD due to limited IC-specific research.
  • The natural history of IC often resembles UC.
  • Future IBD therapies may offer insights for IC treatment.