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Primary Intraosseous Synovial Sarcoma in the Mandible
Lucas Novaes Teixeira1, Eduardo Zambaldi da Cruz1, Ana Cláudia Garcia Rosa1,2
1Faculdade São Leopoldo Mandic, Rua José Rocha Junqueira 13, Swift, 13045-755 Campinas, SP, Brazil.
Case Reports in Oncological Medicine
|December 8, 2021
Summary
This study reports a rare case of primary intraosseous synovial sarcoma (SS) in the mandible of a young male. Diagnosis involved clinical, imaging, and immunohistochemical analysis of the rare mandibular tumor.
Area of Science:
- Oral oncology
- Pathology
- Radiology
Background:
- Synovial sarcoma (SS) is a rare malignant mesenchymal tumor typically found in extremities.
- Intraosseous occurrence in the head and neck, particularly the mandible, is exceptionally uncommon.
Observation:
- A 22-year-old male presented with a painful mandibular swelling.
- Imaging revealed an expansive, multilocular radiolucent lesion in the left mandible.
- Differential diagnoses included ameloblastoma and other malignant neoplasms.
Findings:
- Histological examination showed spindle cell proliferation with specific nuclear features.
- Immunohistochemistry confirmed SS with positive markers (AE1/AE3, CK7, vimentin, CD-99, TLE-1) and negative markers (CD-34, S-100, SMA, HHF-35).
- The final diagnosis was primary intraosseous synovial sarcoma of the mandible.
Implications:
- This case highlights the importance of considering rare diagnoses like synovial sarcoma in mandibular lesions.
- Accurate diagnosis relies on integrating clinical, radiological, and detailed immunohistochemical findings.
- Understanding the presentation of rare intraosseous tumors aids in timely and appropriate patient management.
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