Association between interleukin-17F rs763780 polymorphism and psoriasis risk: A meta-analysis

Area of Science:

• Genetics
• Immunology
• Dermatology

Background:

• The interleukin-17F (IL-17F) rs763780 polymorphism is a potential factor in psoriasis development.
• Previous research suggests a probable association between this genetic variation and increased psoriasis risk.

Purpose of the Study:

• To provide a more definitive estimation of the association between the IL-17F rs763780 T/C polymorphism and the risk of developing psoriasis.
• To consolidate existing evidence through a meta-analysis.

Main Methods:

• A systematic literature search was conducted across multiple databases (PubMed, EMBASE, etc.) for relevant case-control studies.
• Two independent reviewers screened studies and extracted data on odds ratios and confidence intervals for the IL-17F rs763780 polymorphism in psoriasis patients versus controls.
• Meta-analysis was performed to pool the data from seven identified studies.

Main Results:

• Seven case-control studies involving 1824 cases and 1585 controls were included in the meta-analysis.
• The pooled analysis revealed that the IL-17F rs763780 C allele is a significant risk factor for psoriasis.
• Subgroup analysis by ethnicity indicated a strong association between the C allele and increased psoriasis risk in Asian populations, but not in Caucasians.

Conclusions:

• The meta-analysis suggests a significant association between the IL-17F rs763780 T/C polymorphism and psoriasis risk, especially in Asian individuals.
• Current data is limited due to the small number of studies and focus on a single gene site.
• Further research is recommended to explore the impact of other genetic polymorphisms and confounding factors.