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Updated: Aug 2, 2026

Nucleoside Triphosphates - From Synthesis to Biochemical Characterization
Published on: April 3, 2014
Domino Michael/Michael reaction catalyzed by switchable modularly designed organocatalysts
Ramarao Parella1, Satish Jakkampudi1, Pranjal Bora1
1Department of Chemistry, University of Texas at San Antonio, One UTSA Circle, San Antonio, Texas 78249-069, USA. cong.zhao@utsa.edu.
Abstract:
The domino Michael/Michael reaction between (E)-7-aryl-7-oxohept-5-enals and trans-cinnamaldehydes was investigated by using modularly designed organocatalysts (MDOs). It was found that both the enamine and iminium catalytic modes of the MDOs are switchable and can be individually switched on and off by using appropriate combinations of the precatalyst modules and the reaction conditions. When both the enamine and iminium catalysis modes of the MDOs are switched on, the desired domino reaction products can be obtained in good yields and stereoselectivities under optimized conditions.
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