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Updated: Oct 10, 2025

Isolation, Characterization and Functional Examination of the Gingival Immune Cell Network
Published on: February 16, 2016
The Th17/Treg cell balance: crosstalk among the immune system, bone and microbes in periodontitis
Jianwen Deng1, Chunting Lu2, Qingtong Zhao1
1Clinical Research Platform for Interdiscipline of Stomatology, The First Affiliated Hospital of Jinan University, Department of Stomatology, College of stomatology, Jinan University, Guangzhou, China.
Abstract:
Periodontopathic bacteria constantly stimulate the host, which causes an immune response, leading to host-induced periodontal tissue damage. The complex interaction and imbalance between Th17 and Treg cells may be critical in the pathogenesis of periodontitis. Furthermore, the RANKL/RANK/OPG system plays a significant role in periodontitis bone metabolism, and its relationship with the Th17/Treg cell imbalance may be a bridge between periodontal bone metabolism and the immune system. This article reviews the literature related to the Th17/Treg cell imbalance mediated by pathogenic periodontal microbes, and its mechanism involving RANKL/RANK/OPG in periodontitis bone metabolism, in an effort to provide new ideas for the study of the immunopathological mechanism of periodontitis.
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