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A review on bovine hydroxyapatite; extraction and characterization.

Ali Moradi1,2, Majid Pakizeh3, Toktam Ghassemi4

  • 1Clinical Research Development Unit, Ghaem Hospital, Mashhad University of Medical Sciences (MUM), Mashhad, Iran.

Biomedical Physics & Engineering Express
|December 8, 2021
PubMed
Summary

Hydroxyapatite (HA) derived from bovine bone offers promising properties for bone tissue engineering. This review details HA extraction and characterization, highlighting its potential as an optimal bone substitute material.

Keywords:
HAbone graftbovinecharacterizationhydroxyapatite

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Area of Science:

  • Biomaterials Science
  • Biomineralization
  • Orthopedic Engineering

Background:

  • Bone grafting surgeries necessitate advanced bone substitutes.
  • Hydroxyapatite (HA), the primary mineral component of bone, shows significant regenerative potential.
  • Mimicking bone's porous structure and biological functions is key for effective tissue engineering.

Purpose of the Study:

  • To review methods for extracting Hydroxyapatite (HA) from bovine bone.
  • To highlight critical steps in the HA extraction process.
  • To discuss the characterization and future development of HA-based bone constructs.

Main Methods:

  • Review of scientific literature on HA extraction from bovine sources.
  • Detailed explanation of characterization techniques including XRD, FTIR, SEM, TEM, mechanical/thermodynamic tests, and bioactivity analysis.
  • Synthesis of information on essential extraction parameters.

Main Results:

  • Bovine bone is a viable source for Hydroxyapatite (HA) extraction.
  • Established characterization methods confirm the quality and properties of extracted HA.
  • The review provides a comprehensive overview of HA extraction and analysis.

Conclusions:

  • Hydroxyapatite (HA) extracted from bovine bone is a suitable biomaterial for bone tissue engineering.
  • Understanding extraction and characterization is crucial for developing effective HA bone substitutes.
  • Further development of HA constructs holds promise for orthopedic applications.