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Related Experiment Video

Updated: Oct 10, 2025

A Battery of Motor Tests in a Neonatal Mouse Model of Cerebral Palsy

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Sixth Nerve Palsy in Children Etiology, Long-Term Course, and a Diagnostic Algorithm.

Firas Abu Hanna¹, Haneen Jabaly-Habib^2,3, Orly Halachmi-Eyal^4,5

¹Department of Pediatrics B, 61172Emek Medical Center, Afula, Israel.

Journal of Child Neurology

|December 9, 2021

Summary

Acute onset sixth cranial nerve palsy in children has varied causes. Increased intracranial pressure and anti-GQ1B syndrome were most common. Neuroimaging and selective lab tests aid diagnosis.

Keywords:

Guillain-Barré syndrome Miller Fisher syndrome anti-GQ1b anti-MOG cranial nerve palsy

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Last Updated: Oct 10, 2025

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Structured Motor Rehabilitation After Selective Nerve Transfers

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Published on: August 15, 2019

Area of Science:

Pediatric Neurology
Ophthalmology
Neuro-ophthalmology

Background:

Acute onset strabismus in children raises concern for sixth cranial nerve palsy.
The diagnostic approach for sixth nerve palsy remains debated.
Identifying underlying etiologies is crucial for appropriate management.

Purpose of the Study:

To determine common causes of sixth nerve palsy in pediatric patients.
To propose a practical diagnostic algorithm for pediatric sixth nerve palsy.

Main Methods:

Retrospective review of pediatric patient records (January 2014 - April 2020).
Inclusion criteria: diagnoses including sixth nerve palsy, Guillain-Barré syndrome, and others (ICD-9).
Data extraction: clinical presentation, history, diagnostic work-up (serology, CSF, neuroimaging).

Main Results:

Seventeen pediatric patients with sixth nerve palsy were identified.
Most frequent etiologies: increased intracranial hypertension and anti-GQ1B syndrome (3 patients each).

Conclusions:

Etiologies of pediatric sixth nerve palsy are diverse.
Recommend neuroimaging for all patients.
Consider serum and cerebrospinal fluid testing in select cases.
Combined neuroimaging and laboratory testing facilitate diagnosis.