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Stimuli-responsive Polymeric Nanosystems for Therapeutic Applications.

Mayank Handa1, Ajit Singh1, Swaran Jeet Singh Flora1

  • 1Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER)-Raebareli, Lucknow, Uttar Pradesh 226002, India.

Current Pharmaceutical Design
|December 9, 2021
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Summary

Polymeric nanoparticles offer targeted drug delivery, releasing medications precisely where needed. These smart nanocarriers respond to stimuli, enhancing therapeutic effectiveness for various disorders.

Keywords:
cancerdrug deliveryneurodegenerationpH-responsivepolymeric nanoparticlestemperature responsive

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Drug Delivery Systems

Background:

  • Polymeric nanoparticles are emerging as advanced carriers for controlled and targeted drug delivery.
  • Stimuli-responsive nanocarriers ensure high drug uptake at target sites with minimal leakage.
  • These systems functionalize various nanocarriers, including dendrimers, metallic nanoparticles, and liposomes.

Purpose of the Study:

  • To review the therapeutic potential of smart stimuli-responsive carriers.
  • To examine the behavior of these carriers in response to internal and external stimuli (pH, temperature, redox, light, magnetic field).
  • To highlight recent advancements in polymeric materials for stimuli-responsive drug delivery.

Main Methods:

  • Literature review of stimuli-responsive drug delivery systems.
  • Analysis of in vitro and in vivo studies on carrier behavior and drug release patterns.
  • Examination of the physical properties of polymeric materials used in these systems.

Main Results:

  • Stimuli-responsive nanocarriers demonstrate varied drug release profiles under different stimuli.
  • These systems effectively deliver both hydrophilic and hydrophobic drugs.
  • Recent developments focus on enhancing the physical properties of polymers for targeted delivery.

Conclusions:

  • Stimuli-responsive drug delivery systems enable site-specific treatment for conditions like cancer and neurodegenerative disorders.
  • The field of stimuli-responsive nanocarriers is rapidly advancing.
  • There is a significant demand for biocompatible and biodegradable responsive polymers for safe and effective drug delivery.