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Regulatory Functions of Protein Tyrosine Phosphatase Receptor Type O in Immune Cells

Feiling Xie1,2, Hongmei Dong1,2, Hao Zhang1,2,3,4

  • 1Institute of Precision Cancer Medicine and Pathology, School of Medicine, Jinan University, Guangzhou, China.

Frontiers in Immunology
|December 9, 2021
PubMed

Insights

Protein tyrosine phosphatase receptor type O (PTPRO) and its truncated form (PTPROt) are crucial in immune cells. This review details their regulatory roles and molecular mechanisms in B cells, T cells, and macrophages.

Area of Science:

  • Immunology
  • Cell Biology
  • Biochemistry

Background:

  • Protein tyrosine phosphatases (PTPs) are critical regulators of cellular signaling pathways.
  • Protein tyrosine phosphatase receptor type O (PTPRO) is an R3 receptor-like PTP.
  • The truncated PTPRO (PTPROt) isoform is predominantly expressed in hematopoietic and immune cells.

Purpose of the Study:

  • To review the regulatory roles of PTPRO and PTPROt in immune cells.
  • To elucidate the molecular mechanisms underlying PTPRO/PTPROt function in immunity.
  • To focus on the impact of PTPRO/PTPROt in B cells, T cells, and macrophages.

Main Methods:

  • Literature review of existing studies on PTPRO and PTPROt.
  • Analysis of signaling pathways regulated by PTPRO/PTPROt.
  • Examination of PTPRO/PTPROt expression patterns in immune cells.

Main Results:

  • PTPROt is significantly expressed in various immune cell types, including B cells, T cells, and macrophages.
  • PTPRO/PTPROt influences key immune cell processes such as growth, differentiation, and activation.
  • Specific molecular mechanisms of PTPRO/PTPROt in immune regulation are being uncovered.

Conclusions:

  • PTPRO and its truncated form PTPROt play vital roles in immune cell function.
  • Understanding PTPRO/PTPROt mechanisms is crucial for comprehending immune responses.
  • Further research into PTPRO/PTPROt is warranted for potential immunomodulatory applications.
Keywords:
B cellsPTPROPTPROtT cellsmacrophagesprotein tyrosine phosphatases

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