Proteus syndrome in pregnancy: A case report.

Area of Science:

• Genetics
• Maternal-Fetal Medicine
• Rare Diseases

Background:

• Proteus syndrome is a rare genetic disorder characterized by mosaic overgrowth of multiple tissues, primarily affecting skeletal and cutaneous systems.
• Published literature on Proteus syndrome is limited, with a scarcity of case reports, especially concerning pregnancy management.

Observation:

• This report details the first documented case of Proteus syndrome management during a patient's first pregnancy.
• The case involved a pregnant woman with Proteus syndrome managed at a large teaching hospital.

Findings:

• The management of Proteus syndrome in pregnancy necessitates careful consideration of its multi-systemic nature.
• Specific challenges were identified and addressed across antenatal, intrapartum, and postnatal care phases.

Implications:

• This case provides valuable insights for clinicians managing pregnant patients with rare genetic syndromes like Proteus syndrome.
• Improved understanding of Proteus syndrome in pregnancy can enhance patient outcomes and inform future clinical guidelines.