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MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...

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Updated: Oct 10, 2025

Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease

Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease

Published on: July 3, 2018

MicroRNAs: A Neoteric Approach to Understand Pathogenesis, Diagnose, and Treat Myocardial Infarction.

Nida Irfan Sayed-Pathan^1,2, Pramod Kumar^1,2, Kishore M Paknikar^1,2

¹Nanobioscience Group, Agharkar Research Institute, Pune, India; and.

Journal of Cardiovascular Pharmacology

|December 9, 2021

Summary

MicroRNAs (miRNAs) are key regulators of heart repair after myocardial infarction. Targeting these molecules in cardiomyocytes offers a promising therapeutic strategy to improve cardiac function and regeneration post-heart attack.

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Preparation of a Non-Cardiomyocyte Cell Suspension for Single-Cell RNA Sequencing from a Post-Myocardial Infarction Adult Mouse Heart

Preparation of a Non-Cardiomyocyte Cell Suspension for Single-Cell RNA Sequencing from a Post-Myocardial Infarction Adult Mouse Heart

Published on: February 3, 2023

Area of Science:

Cardiovascular Science
Molecular Biology
Regenerative Medicine

Background:

Myocardial infarction (MI) is a leading cause of global mortality from ischemic heart disease.
Post-MI cardiac dysfunction involves cardiomyocyte damage, leading to adverse remodeling like hypertrophy and fibrosis.
MicroRNAs (miRNAs) are critical regulators of cellular processes, including cardiomyocyte survival and regeneration.

Purpose of the Study:

To review the role of specific miRNAs in cardiomyocyte repair and regeneration following myocardial infarction.
To explore the therapeutic potential of targeting miRNAs for reversing adverse cardiac remodeling post-MI.

Main Methods:

Literature review of studies investigating miRNA function in cardiac repair.
Analysis of miRNA expression patterns in post-myocardial infarction models.
Synthesis of current knowledge on miRNA-mediated pathways in cardiomyocytes.

Main Results:

Specific miRNAs significantly influence cardiomyocyte survival, proliferation, and differentiation.
Dysregulated miRNA expression is linked to pathological cardiac remodeling post-MI.
miRNA-based therapies show potential in preclinical models to restore cardiac function.

Conclusions:

MicroRNAs are crucial players in the complex processes of cardiac repair and regeneration post-MI.
Targeting specific miRNAs presents a viable therapeutic avenue for treating heart disease.
Further research into miRNA therapeutics could lead to novel treatments for myocardial infarction patients.