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Related Experiment Videos

Bepridil abolishes exercise-induced regional contractile dysfunction in dogs.

G Krumpl, N Mayer, W Schneider

    International Journal of Cardiology
    |July 1, 1986
    PubMed
    Summary

    Bepridil, a calcium antagonist, significantly improved exercise-induced cardiac dysfunction in dogs by reducing heart rate and improving contractile function. This suggests bepridil may effectively treat angina pectoris.

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    Area of Science:

    • Cardiology
    • Pharmacology
    • Exercise Physiology

    Background:

    • Exercise-induced angina pectoris is a significant clinical challenge.
    • Calcium antagonists are a potential therapeutic class for managing ischemic heart conditions.
    • Understanding the specific effects of bepridil on cardiac function during exercise is crucial.

    Purpose of the Study:

    • To investigate the effects of bepridil on hemodynamic parameters and regional contractile function during exercise in a canine model.
    • To assess the efficacy of bepridil in mitigating exercise-induced cardiac dysfunction.

    Main Methods:

    • Six dogs were instrumented for chronic monitoring of left ventricular pressure, regional contractile function (sonomicrometry), and coronary artery flow.
    • A partially stenosed circumflex artery model was used to induce exercise-related regional contractile dysfunction.

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  • Bepridil was administered intravenously (2 mg/kg) after establishing reproducible exercise-induced dysfunction.

    • Main Results:

    • Exercise consistently induced regional contractile dysfunction in the territory of the stenosed coronary artery.
    • Intravenous bepridil administration minimally improved dysfunction in the first post-drug run and completely abolished it in the subsequent two runs.
    • Bepridil reduced exercise-induced increases in heart rate and left ventricular end-diastolic pressure, and decreased end-diastolic segment length.

    Conclusions:

    • Bepridil demonstrates a beneficial effect in abolishing exercise-induced regional cardiac dysfunction in this canine model.
    • The drug's positive effects are partly attributed to its favorable hemodynamic actions during exercise.
    • These findings support clinical observations and suggest bepridil's potential utility in treating exercise-induced angina pectoris.