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Updated: Oct 10, 2025

Isolation of CD133+ Liver Stem Cells for Clonal Expansion
Published on: October 10, 2011
The role of mesenchymal stem cells in liver injury
Haoyu Sun1, Chuanyin Shi1, Zhenlong Ye1
1Shanghai Cell Therapy Group, Shanghai, China.
Abstract:
Recently, mesenchymal stem cell (MSC) therapy has been suggested as an effective alternative approach for the treatment of hepatic diseases. MSCs have potential therapeutic value, because they have high self-renewal ability, are capable of multipotent differentiation, and have low immunogenicity. Furthermore, MSCs have the potential to differentiate into hepatocytes, and the therapeutic value exists in their immune-modulatory properties and secretion of trophic factors, such as growth factors and cytokines. Moreover, MSCs can suppress inflammatory responses, reduce hepatocyte apoptosis, increase hepatocyte regeneration, regress liver fibrosis, and enhance liver functionality.
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