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Updated: Oct 10, 2025

Bioluminescent Bacterial Imaging In Vivo
Published on: November 4, 2012
Engineered bacteria recycle tumor metabolic waste to boost immunotherapy
Juan R Cubillos-Ruiz1, Andres Cubillos-Ruiz2
1Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY 10065, USA; Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA.
None:
A recent study published in Nature by Canale et al. (2021) shows that engineered probiotic bacteria can be used to augment the availability of nutrients required for optimal immune cell function in tumors. This approach enhances anti-tumor immunity and improves the efficacy of immunotherapy in mouse models of cancer.
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