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Brain organization in schizophrenia.

N D Volkow, J D Brodie, A P Wolf

    Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
    |August 1, 1986
    PubMed
    Summary
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    Schizophrenia alters brain metabolism patterns, particularly in frontal and subcortical regions. These metabolic differences, not just individual region activity, distinguish patients from controls and task conditions.

    Area of Science:

    • Neuroscience
    • Medical Imaging
    • Psychiatry

    Background:

    • Schizophrenia is a complex psychiatric disorder.
    • Understanding brain metabolism alterations is crucial for diagnosis and treatment.

    Purpose of the Study:

    • To investigate regional brain metabolism differences between normal subjects and schizophrenic patients.
    • To examine how brain metabolism changes during a visual task.

    Main Methods:

    • Positron emission tomography (PET) with [11C]deoxyglucose was used.
    • Metabolic data from 11 brain regions were analyzed using factor analysis.
    • Subjects included 12 normal controls and 18 schizophrenic patients.

    Main Results:

    • Four distinct metabolic patterns were identified: frontal, occipital, hemispheric, and subcortical.

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  • Frontal and subcortical metabolic factors differentiated schizophrenic patients from controls.
  • Occipital metabolic factors distinguished between baseline and visual task conditions.

    • Conclusions:

    • The pattern of regional brain metabolic activity, not individual region metabolism, is key in distinguishing schizophrenia.
    • Brain metabolism analysis using PET offers insights into the pathophysiology of schizophrenia.