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Related Concept Videos

Fungal Group Zygomycota01:29

Fungal Group Zygomycota

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Zygomycota, previously classified as a distinct fungal group, are primarily terrestrial, saprophytic molds that play a crucial role as decomposers. Recent phylogenetic studies have revealed that these fungi are now divided into two major clades — Mucoromycota, which includes many symbiotic species, and Zoopagomycota, which primarily consists of parasitic and pathogenic fungi. These groups exhibit distinct ecological roles and reproductive strategies while sharing key structural and...
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Fungal Phylum Basidiomycota01:26

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Basidiomycota is a diverse phylum of fungi that includes ecologically significant decomposers such as white rot fungi, symbionts like mycorrhizal fungi, plant pathogens such as rusts and smuts, and edible species like Agaricus bisporus (the common button mushroom). These fungi play crucial roles in nutrient cycling, symbiotic relationships, and even human health. Their defining feature is the basidium, a microscopic club-shaped structure responsible for producing basidiospores.Fruiting Bodies...
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Fungal Phylum Microsporidia01:28

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Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...
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Fungal Phylum Ascomycota01:28

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Phylum Ascomycota, a major division within the subkingdom Dikarya, comprises a diverse range of fungal species, including both unicellular yeasts and filamentous molds such as Aspergillus and Penicillium. These fungi thrive in a variety of habitats, from aquatic ecosystems to terrestrial environments, playing crucial ecological and economic roles.Morphology and ReproductionThe defining characteristic of Ascomycetes, commonly referred to as sac fungi, is the ascus—a sac-like structure that...
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Listeria monocytogenes Infection of the Brain
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Fungal Abscess in the Brain.

Jacob L Goldberg1, Alexandra Giantini-Larsen1, Cameron W Brennan2

  • 1Department of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA; Department of Neurosurgery, Weill Cornell Medical College, New York, New York, USA.

World Neurosurgery
|December 9, 2021
PubMed
Summary

A 67-year-old male with chronic lymphocytic leukemia developed headaches and brain lesions. Diagnosis confirmed an invasive fungal infection via stereotactic brain biopsy.

Keywords:
Fungal light microscopyRing-enhancing abscessStereotactic brain biopsy

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Area of Science:

  • Neurology
  • Infectious Diseases
  • Oncology

Background:

  • Chronic lymphocytic leukemia (CLL) is a hematologic malignancy.
  • Patients with CLL often receive immunosuppressive therapies.
  • Standard prophylaxis includes trimethoprim-sulfamethoxazole for Pneumocystis jirovecii pneumonia.

Observation:

  • A 67-year-old male with CLL presented with headaches.
  • Brain magnetic resonance imaging (MRI) revealed ring-enhancing lesions.
  • The patient was on rituximab and ibrutinib for CLL treatment.

Findings:

  • Stereotactic brain biopsy was performed for diagnosis.
  • Light microscopy identified an invasive fungal infection.
  • The fungal infection was the cause of the brain lesions.

Implications:

  • Invasive fungal infections can present as brain lesions in immunocompromised patients.
  • Early diagnosis via biopsy is crucial for effective treatment.
  • This case highlights the importance of considering fungal infections in CLL patients with neurological symptoms.