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Percutaneous Hepatic Perfusion (PHP) with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver
09:02

Percutaneous Hepatic Perfusion (PHP) with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver

Published on: July 31, 2016

Hemorrhagic complications of piperacillin therapy

M Lee, M Stobnicki, R Sharifi

    The Journal of Urology
    |August 1, 1986
    PubMed

    Insights

    Hemorrhage from extended spectrum anti-Pseudomonas penicillins like piperacillin is rare. This report details two cases of piperacillin-induced bleeding and discusses its incidence, mechanism, and management.

    Area of Science:

    • Pharmacology
    • Hematology
    • Infectious Diseases

    Background:

    • Extended spectrum anti-Pseudomonas penicillins are crucial in treating severe infections.
    • Clinically significant hemorrhage is an uncommon but serious adverse effect associated with these antibiotics.

    Observation:

    • Two patients experienced bleeding complications attributed to piperacillin therapy.
    • These cases highlight a potential, albeit infrequent, risk of this antibiotic class.

    Findings:

    • The incidence and underlying mechanisms of piperacillin-induced bleeding were reviewed.
    • Piperacillin, like other extended spectrum penicillins, may interfere with hemostasis.

    Implications:

    • Awareness of this adverse reaction is important for clinicians.
    • Management strategies for patients experiencing hemorrhage during piperacillin treatment are suggested.

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