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Updated: Oct 10, 2025

Applying Advanced In Vitro Culturing Technology to Study the Human Gut Microbiota
Published on: February 15, 2019
Implications of Gut Microbiota in Complex Human Diseases
Dahai Yu1, Xin Meng1, Willem M de Vos2,3
1Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, 2699 Qianjin Street, Changchun 130012, China.
Gut microbes influence human health throughout life, affecting diseases like metabolic disorders and cancer. Fecal Microbial Transplantation (FMT) shows promise as a novel clinical strategy for disease treatment.
Area of Science:
- Microbiology
- Human Health
- Gastroenterology
Background:
- Gut microbes are integral to human health across the lifespan.
- Microbial balance is influenced by environmental factors, lifestyle, and age.
- Diet, prebiotics, and antibiotics can modulate gut microbes to impact health.
Purpose of the Study:
- To review the role of gut microbes in metabolic, gastrointestinal, neurological, immune diseases, and cancer.
- To discuss host-microbe interactions, including beneficial and harmful effects.
- To evaluate Fecal Microbial Transplantation (FMT) as a potential clinical strategy.
Main Methods:
- Literature review focusing on the impact of gut microbiota on various diseases.
- Analysis of host-microbe interactions and their molecular mediators.
- Evaluation of Fecal Microbial Transplantation (FMT) efficacy.
Main Results:
- Gut microbes play a significant role in the pathogenesis and progression of numerous diseases.
- Host-microbe interactions involve metabolites, enzymes, and inflammatory molecules.
- Fecal Microbial Transplantation (FMT) demonstrates potential for treating diverse conditions.
Conclusions:
- Gut microbiota are critical determinants of human health and disease.
- Understanding host-microbe interactions is key to developing new therapies.
- Fecal Microbial Transplantation (FMT) represents a promising frontier in clinical medicine.
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