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Updated: Oct 10, 2025

Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence
Published on: May 22, 2013
Regulation of Gene Expression by Telomere Position Effect
Kyung-Ha Lee1, Do-Yeon Kim2, Wanil Kim3
1Division of Cosmetic Science and Technology, Daegu Haany University, Gyeongsan 38610, Korea.
Aging and epigenetic regulation are linked to geriatric diseases. Telomere shortening, a key aging event, impacts gene expression and genome structure, offering insights into disease pathogenesis and potential therapies.
Area of Science:
- Gerontology
- Molecular Biology
- Genetics
Background:
- Malignant tumors in the elderly significantly impact quality of life.
- Understanding the aging-pathogenesis link in geriatric diseases is crucial for effective treatment development.
- Epigenetic regulation via chromatin structure changes is increasingly recognized as vital in the aging process.
Purpose of the Study:
- To review the role of telomere shortening in age-dependent genomic structural changes and gene expression shifts.
- To provide insights into how telomere shortening affects pathogenesis in disease-affected cells.
- To suggest novel therapeutic strategies targeting telomere shortening in aging-related diseases.
Main Methods:
- Literature review focusing on aging, epigenetics, telomere shortening, and geriatric diseases.
- Analysis of studies examining genomic structural changes and gene expression patterns during aging.
- Synthesis of current research on the impact of telomere shortening on cellular aging and disease.
Main Results:
- Telomere shortening is a prominent feature of cellular aging.
- Shortened telomeres contribute to genome rearrangement and affect global gene expression.
- These changes are implicated in the pathogenesis of age-related diseases.
Conclusions:
- Telomere shortening plays a significant role in the aging process and disease development.
- Understanding these mechanisms can reveal novel therapeutic targets.
- Further research into telomere dynamics may lead to innovative treatments for geriatric diseases.
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