Role of Receptors in Relation to Plaques and Tangles in Alzheimer's Disease Pathology

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Detection of Neuritic Plaques in Alzheimer's Disease Mouse Model
06:02

Detection of Neuritic Plaques in Alzheimer's Disease Mouse Model

Published on: July 26, 2011

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Kavita Sharma1, Samjhana Pradhan2, Lawrence K Duffy3

  • 1Biomedical and Pharmaceutical Sciences, College of Pharmacy, Kasiska Division of Health Sciences, Pocatello, ID 83209, USA.

International Journal of Molecular Sciences
|December 10, 2021
PubMed

Insights

Current Alzheimer's disease (AD) treatments offer only symptomatic relief. This review explores targeting major receptors and viral mimicry for novel preventive and curative AD therapies.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Biochemistry

Background:

  • Alzheimer's disease (AD) is characterized by amyloid-beta (Aβ) plaques and neurofibrillary tangles (NFTs).
  • Existing AD therapies primarily manage symptoms and slow neuronal degeneration, lacking curative or fully prophylactic options.
  • The complex pathology of AD necessitates diverse therapeutic strategies for prevention and treatment.

Purpose of the Study:

  • To review the role of receptors as potential therapeutic targets for Alzheimer's disease.
  • To elucidate the involvement of major receptors in AD progression.
  • To explore the potential of viral mimicry as a therapeutic approach in AD.

Main Methods:

  • Literature review focusing on receptor pathways in AD pathogenesis.
  • Analysis of agonists and antagonists for identified key receptors.
  • Exploration of viral mimicry strategies in the context of AD.

Main Results:

  • Identification of specific major receptors implicated in AD progression.
  • Discussion of receptor agonists and antagonists as potential therapeutic agents.
  • Overview of viral mimicry as a novel avenue for AD intervention.

Conclusions:

  • Receptor-targeted therapies offer promising avenues for AD treatment.
  • Understanding receptor pathways is crucial for developing new therapeutic strategies.
  • Viral mimicry presents a novel and potentially effective approach for AD pathology.
Keywords:
Alzheimer’s diseaseG-protein-coupled receptorsN-methyl D-aspartate receptorsamyloid betanicotinic acetylcholine receptorsγ-aminobutyric acid (GABA)

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