Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

ICV-CRH potently affects behavior without altering antinociceptive responding.

J E Sherman, N H Kalin

    Life Sciences
    |August 4, 1986
    PubMed
    Summary

    Corticotropin releasing hormone (CRH) administered intracerebroventricularly induced stress behaviors in rats but did not affect pain relief. Peripheral CRH also failed to produce analgesia, questioning central CRH

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Incidental Findings from 16,400 Brain MRI Examinations of Research Volunteers.

    AJNR. American journal of neuroradiology·2023
    Same author

    Examining the quality of work-life of paramedics in northern Ontario, Canada: A cross-sectional study.

    Work (Reading, Mass.)·2022
    Same author

    Heightened extended amygdala metabolism following threat characterizes the early phenotypic risk to develop anxiety-related psychopathology.

    Molecular psychiatry·2016
    Same author

    Extreme early-life anxiety is associated with an evolutionarily conserved reduction in the strength of intrinsic functional connectivity between the dorsolateral prefrontal cortex and the central nucleus of the amygdala.

    Molecular psychiatry·2014
    Same author

    Evolutionarily conserved prefrontal-amygdalar dysfunction in early-life anxiety.

    Molecular psychiatry·2014
    Same author

    CRHR1 genotypes, neural circuits and the diathesis for anxiety and depression.

    Molecular psychiatry·2012

    Area of Science:

    • Neuroscience
    • Behavioral Neuroscience
    • Endocrinology

    Background:

    • Corticotropin-releasing hormone (CRH) is a key regulator of the stress response.
    • Its potential role in integrating stress-related behaviors, including pain perception (antinociception), is hypothesized.
    • Understanding CRH's central functions is crucial for stress and pain research.

    Purpose of the Study:

    • To investigate the integrative function of CRH in stress-related behaviors and antinociception in rats.
    • To determine if central (intracerebroventricular) administration of CRH influences stress behaviors and pain perception.
    • To compare the effects of central versus peripheral CRH administration.

    Main Methods:

    • Rats received intracerebroventricular (ICV) or peripheral administration of CRH at low (0.3 microgram) and high (3.0 micrograms) doses.
    • Behavioral changes (grooming, walking, burrowing, self-gnawing, pica, rearing, sleeping) were observed.
    • Analgesia was assessed using hot-plate and tail-flick tests, comparing CRH effects to vehicle and morphine controls.

    Main Results:

    • ICV administration of CRH, at both doses, induced significant stress-related behaviors, including increased grooming and decreased sleeping.
    • Peripheral administration of CRH did not produce comparable behavioral changes.
    • Neither central nor peripheral CRH administration demonstrated any significant analgesic effect in the hot-plate or tail-flick tests, unlike morphine.

    Conclusions:

    • Central CRH administration effectively induces stress-related behaviors in rats.
    • CRH does not appear to mediate antinociception, challenging its hypothesized role in integrating pain perception within the stress response.
    • These findings suggest that central CRH systems may not play a significant role in pain modulation.

    Related Experiment Videos