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Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

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Primary Skull Base Chondrosarcomas: A Systematic Review.

Paolo Palmisciano¹, Ali S Haider², Mohammadmahdi Sabahi³

¹Department of Neurosurgery, Trauma Center, Gamma Knife Center, Cannizzaro Hospital, 95126 Catania, Italy.

|December 10, 2021

Summary

Surgical resection and radiotherapy are effective for skull base chondrosarcomas (SBCs), offering good tumor control with manageable complications. This review analyzes treatment outcomes for primary SBCs, aiding clinical decision-making.

Keywords:

chondrosarcoma endoscopy radiation oncology skull base oncology systematic review

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Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery

Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery

Published on: July 5, 2021

Area of Science:

Neurosurgery
Oncology
Radiotherapy

Background:

Primary skull base chondrosarcomas (SBCs) significantly impact patient quality of life.
Surgical resection and radiotherapy are primary treatment modalities but carry risks of debilitating complications.

Purpose of the Study:

To systematically review the literature on primary SBCs.
To analyze clinical characteristics, management strategies, and treatment outcomes for SBCs.

Main Methods:

Comprehensive literature search across PubMed, EMBASE, Scopus, Web-of-Science, and Cochrane databases.
Adherence to PRISMA guidelines for study selection.
Analysis of clinical data, including demographics, surgical approaches, radiotherapy details, complications, and survival rates.

Main Results:

33 studies including 1307 patients were analyzed; middle fossa involvement and cavernous sinus infiltration were common.
Surgical resection (93.3%) was the predominant treatment, with both open and endoscopic approaches utilized.
Radiotherapy was administered to 77.9% of patients, with no significant difference in outcomes based on radiotherapy protocols. Recurrence rates were 16.1%, with favorable 5- and 10-year survival rates.

Conclusions:

Surgical resection and radiotherapy are effective treatments for primary SBCs.
These modalities offer acceptable complication rates and favorable local tumor control.
The findings support current treatment paradigms for SBCs.