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Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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Microfluidic Device for Recreating a Tumor Microenvironment in Vitro
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Going with the Flow: Modeling the Tumor Microenvironment Using Microfluidic Technology.

Hongyan Xie1, Jackson W Appelt1, Russell W Jenkins1,2,3

  • 1Massachusetts General Hospital Cancer Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

Cancers
|December 10, 2021
PubMed
Summary
This summary is machine-generated.

Microfluidic technology offers advanced models for studying the tumor microenvironment (TME) and cancer immunotherapy resistance. These models help researchers understand complex tumor-immune dynamics and develop more effective cancer treatments.

Keywords:
3D tumor modelsmicrofluidicsorganoidsorganotypic culture

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Area of Science:

  • Oncology
  • Immunology
  • Biotechnology

Background:

  • Cancer immunotherapy has revolutionized treatment but faces challenges due to intrinsic and acquired resistance.
  • Understanding tumor-immune dynamics is crucial for overcoming resistance and improving patient outcomes.
  • Current model systems often fail to accurately replicate the complex tumor microenvironment (TME).

Purpose of the Study:

  • To review recent advancements in TME models, particularly those utilizing microfluidic technology.
  • To explore the application of microfluidics in studying tumor-immune interactions and response to cancer therapeutics.
  • To identify limitations of current microfluidic TME models and suggest future research directions.

Main Methods:

  • Review of current literature on TME models and microfluidic technologies.
  • Analysis of how microfluidics can model tumor-immune dynamics.
  • Discussion of microfluidic applications in evaluating cancer therapeutics.

Main Results:

  • Microfluidic technology provides sophisticated platforms for recapitulating the TME.
  • These systems enable detailed study of tumor-immune interactions crucial for immunotherapy response and resistance.
  • Microfluidics facilitates the investigation of therapeutic responses within a controlled microenvironment.

Conclusions:

  • Microfluidic TME models represent a significant advancement for cancer research.
  • Further development is needed to overcome limitations and fully leverage microfluidics for understanding cancer therapies.
  • This technology holds great potential for advancing cancer immunotherapy and drug development.