Related Experiment Video

Updated: Aug 17, 2026

Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation
07:13

Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation

Published on: March 14, 2017

Hypercalciuria, hyperphosphaturia, and growth retardation in children with diabetes mellitus

J I Malone, S Lowitt, J A Duncan

    Pediatrics
    |August 1, 1986
    PubMed

    Insights

    Children with diabetes mellitus often experience growth retardation. Renal losses of calcium and phosphorus, linked to glucosuria, significantly impact their height more than hyperglycemia alone.

    Area of Science:

    • Pediatric Endocrinology
    • Metabolic Disorders
    • Nephrology

    Background:

    • Children with diabetes mellitus (DM) frequently exhibit growth retardation compared to their healthy peers.
    • Investigating the specific factors contributing to poor growth in pediatric DM is crucial for effective management.

    Observation:

    • A cross-sectional study assessed 157 children with DM and 37 non-diabetic siblings.
    • Children with DM showed significantly reduced mean height.
    • Hyperglycemia, hypercalciuria, and hyperphosphaturia were measured alongside height.

    Findings:

    • The duration of diabetes (hyperglycemia) negatively correlated with height, with significant differences emerging after 7 years.
    • Hypercalciuria and hyperphosphaturia were more strongly associated with reduced height than hyperglycemia.
    • Renal wasting of calcium and phosphorus appeared secondary to glucosuria.

    Implications:

    • Hypercalciuria and hyperphosphaturia, known growth inhibitors in non-diabetic children, likely contribute significantly to poor growth in pediatric DM.
    • Understanding these renal mechanisms may lead to targeted interventions to improve growth outcomes in children with diabetes.

    More Related Videos

    Generation of Scaffold-free, Three-dimensional Insulin Expressing Pancreatoids from Mouse Pancreatic Progenitors In Vitro09:33

    Generation of Scaffold-free, Three-dimensional Insulin Expressing Pancreatoids from Mouse Pancreatic Progenitors In Vitro

    Published on: June 2, 2018

    Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice10:31

    Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

    Published on: May 2, 2025

    Related Concept Videos

    Inborn Errors of Metabolism01:20

    Inborn Errors of Metabolism

    Phenylketonuria (PKU) is a protein metabolism disorder characterized by high blood levels of the amino acid phenylalanine. This results from a mutation in the gene responsible for phenylalanine hydroxylase, an enzyme that converts phenylalanine into tyrosine. When this enzyme is deficient, phenylalanine builds up in the blood, leading to symptoms such as vomiting, rashes, seizures, growth deficiency, and severe mental retardation. An early diagnosis and a diet restricting phenylalanine intake...
    Pathophysiology of Diabetes01:20

    Pathophysiology of Diabetes

    Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
    Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility, suggesting a...
    Urinary Tract Calculi IV: Nutrition Therapy and Prevention01:27

    Urinary Tract Calculi IV: Nutrition Therapy and Prevention

    Management of renal calculi focuses on effective strategies like tailored nutrition and hydration therapy. Adjusting diet and fluid intake reduces stone formation and recurrence, making these interventions simple yet powerful in kidney stone prevention and management.Understanding Kidney StonesKidney stones form when calcium, oxalate, uric acid, and cystine concentrate and crystallize in urine. Factors contributing to their formation include genetic predisposition, certain medical conditions,...
    Type I Diabetes III: Clinical Manifestations01:19

    Type I Diabetes III: Clinical Manifestations

    Type 1 diabetes mellitus typically presents with rapid-onset symptoms due to the body’s inability to utilize glucose in the absence of insulin. Since insulin is required for glucose uptake into cells, its deficiency leads to hyperglycemia and cellular energy deprivation, resulting in characteristic clinical features.Polyuria and PolydipsiaOne of the earliest, most prominent symptoms is polyuria (excessive urination). When blood glucose concentrations rise above the renal threshold, the kidneys...
    Hyperglycemia01:29

    Hyperglycemia

    Hyperglycemia is an abnormally high blood glucose level. It is diagnosed by fasting glucose ≥126 mg/dL, 2-hour oral glucose tolerance test (or OGTT) ≥200 mg/dL, random glucose ≥200 mg/dL with symptoms, or HbA1c ≥6.5%. However, HbA1c results may be unreliable in certain conditions, such as anemia or hemoglobinopathies, and the diagnosis should be confirmed unless classic symptoms are present. Postprandial hyperglycemia is typically considered significant when glucose levels exceed 180 mg/dL two...
    Diabetic Nephropathy01:28

    Diabetic Nephropathy

    Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...