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BSC-1 growth inhibitor/type beta transforming growth factor is a strong inhibitor of thymocyte proliferation

H J Ristow

    Proceedings of the National Academy of Sciences of the United States of America
    |August 1, 1986
    PubMed

    Growth inhibitor/type beta transforming growth factor purified from BSC-1 cells and human platelets is shown to strongly inhibit the proliferation of Con A-stimulated mouse thymocytes. The inhibition can be achieved with growth inhibitor/type beta transforming growth factor concentrations approximately equal to 1/10th those necessary to inhibit keratinocyte cultures. The inhibitory effect in thymocyte cultures can be reversed by the addition of interleukin 2. These findings suggest that growth inhibitor/type beta transforming growth factor is a naturally occurring immunoregulator.

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