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Bioengineering artificial blood vessels from natural materials.
Matthew J Moore1, Richard P Tan1, Nianji Yang1
1School of Medical Sciences, Faculty of Health and Medicine, University of Sydney, NSW 2006, Australia; Charles Perkins Centre, University of Sydney, NSW 2006, Australia.
Trends in Biotechnology
|December 10, 2021
Summary
Developing effective small diameter vascular grafts for bypass surgery is challenging. This study identifies promising natural materials for creating durable artificial vascular grafts when patient
Area of Science:
- Biomaterials Science
- Vascular Surgery
- Tissue Engineering
Background:
- Small diameter artificial vascular grafts (<6 mm) are needed for bypass surgery when autologous grafts are unavailable.
- Current synthetic grafts lack elasticity and elicit adverse biological responses.
- Existing tissue-engineered grafts have not met clinical expectations.
Purpose of the Study:
- To identify suitable natural materials for fabricating durable, small diameter vascular grafts.
- To address the limitations of current synthetic and tissue-engineered vascular grafts.
Main Methods:
- Literature review and material property analysis.
- Identification of natural materials with potential for vascular graft applications.
Main Results:
- A specific subset of natural materials demonstrates potential for creating robust acellular conduits.
- These materials offer a promising alternative to synthetic and current tissue-engineered grafts.
Conclusions:
- Natural materials present a viable and attractive option for developing next-generation small diameter vascular grafts.
- Further research into these identified natural materials is warranted for clinical translation.
