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Use of glucose for pain management in premature neonates: a systematic review and meta-analysis protocol

Débora Joyce Duarte Oliveira1, Kleyton Santos Medeiros1, Ayane Cristine Alves Sarmento1

  • 1Universidade Federal do Rio Grande do Norte, Natal, Brazil.

BMJ Open
|December 10, 2021
PubMed

Insights

This systematic review evaluates glucose for pain relief in preterm infants. Further research is needed to standardize effective glucose concentrations and dosages for neonatal pain management.

Area of Science:

  • Neonatal Medicine
  • Pain Management
  • Pharmacology

Background:

  • Effective therapeutic management of neonatal pain is crucial for optimal infant development.
  • Glucose has demonstrated analgesic properties, but optimal concentrations and dosages require standardization.
  • Preterm infants are particularly vulnerable to pain and its long-term developmental consequences.

Purpose of the Study:

  • To systematically review and meta-analyze the efficacy of glucose as an analgesic in preterm infants.
  • To identify optimal glucose concentrations and dosages for neonatal pain management.

Main Methods:

  • Comprehensive literature search of multiple databases (e.g., PubMed, Embase, Scopus) for randomized controlled trials.
  • Inclusion of studies investigating glucose for pain control in premature neonates, with pain relief as the primary outcome.
  • Data extraction and risk of bias assessment by three independent reviewers, with quantitative synthesis if studies are homogeneous.

Main Results:

  • The review aims to synthesize data on glucose's effectiveness in reducing pain in preterm infants.
  • Analysis will determine if current evidence supports standardized glucose concentrations and dosages for neonatal analgesia.
  • Heterogeneity will be assessed using I² statistics to guide quantitative synthesis.

Conclusions:

  • Findings will inform clinical practice regarding the use of glucose for pain management in preterm neonates.
  • This systematic review will highlight the need for standardized protocols for glucose administration.
  • The results will contribute to improving the therapeutic management of pain in vulnerable infant populations.
Abstract

Keywords:
neonatal intensive & critical careneonatologytherapeutics

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