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Advances in Tissue Engineering and Implications for Oral and Maxillofacial Reconstruction
Caitlyn M McGue1, Victoria A Mañón2, Chi T Viet1
1Department of oral and maxillofacial surgery at the Loma Linda University School of Dentistry.
Journal of the California Dental Association
|December 10, 2021
Summary
Tissue engineering using stem cells offers promising solutions for complex oral and maxillofacial reconstruction. This review explores advancements in hard and soft tissue regeneration, nerve repair, and defect reconstruction.
Area of Science:
- Oral and Maxillofacial Surgery
- Regenerative Medicine
- Biomaterials Science
Background:
- Oral and maxillofacial reconstruction presents significant challenges due to intricate facial anatomy and composite defects (soft tissue, bone, nerve).
- Current reconstruction methods include autologous grafts, allografts, xenografts, and prosthetics, each with limitations.
Purpose of the Study:
- To review tissue engineering strategies for oral and maxillofacial reconstruction.
- To highlight advancements in regenerative therapies for specialists treating complex facial defects.
Main Methods:
- Review of current literature on tissue engineering applications in oral and maxillofacial surgery.
- Focus on stem cell-based therapies and their role in regeneration.
Main Results:
- Tissue engineering, particularly with stem cells, shows significant promise for improving reconstructive outcomes.
- Advancements include hard tissue regeneration for dental rehabilitation, soft tissue engineering, and nerve regeneration.
Conclusions:
- Tissue engineering offers innovative strategies for reconstructing major oral and maxillofacial defects.
- These regenerative approaches have the potential to enhance current reconstructive options and patient outcomes.
