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In Vivo Imaging of Cerebrospinal Fluid Transport through the Intact Mouse Skull using Fluorescence Macroscopy
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A clinical primer for the glymphatic system.
Lucas P Carlstrom1, Ahmed Eltanahy1, Avital Perry1
1Departments of Neurologic Surgery, Mayo Clinic, Rochester, MN 55905 USA.
Brain : a Journal of Neurology
|December 10, 2021
Summary
The brain
Area of Science:
- Neuroscience
- Fluid Dynamics
- Cell Biology
Background:
- The brain's fluid dynamics are crucial for neurological health.
- The glial-lymphatic (glymphatic) system facilitates cerebrospinal fluid (CSF) movement and waste clearance.
- Disruptions in glymphatic function are linked to various neurological conditions.
Purpose of the Study:
- To provide a multidisciplinary overview of the glymphatic system.
- To review evidence on glymphatic structure, function, and disease relevance.
- To discuss emerging technologies and translational opportunities in glymphatic research.
Main Methods:
- Review of existing literature on glymphatic system.
- Analysis of data from rodent models and post-mortem studies.
- Exploration of emerging technologies for glymphatic evaluation.
Main Results:
- The glymphatic system actively channels extracellular fluid, clearing waste products.
- Evidence links impaired glymphatic function to aging, neurodegeneration, and CNS injuries.
- Clinical studies of the glymphatic network remain challenging.
Conclusions:
- The glymphatic system plays a vital role in maintaining brain health.
- Understanding glymphatic dysfunction offers potential therapeutic targets for neurological diseases.
- Further research and technological advancements are needed to fully elucidate glymphatic function and its clinical implications.
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