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Lipoprotein (a) and Hypertension

Natalie C Ward1, Janis M Nolde1, Justine Chan1

  • 1Dobney Hypertension Centre, Medical School, University of Western Australia, Perth, Australia.

Current Hypertension Reports
|December 10, 2021
PubMed

Insights

Elevated lipoprotein (a) is a risk factor for cardiovascular disease. In hypertensive patients, about 30% had high lipoprotein (a) levels, suggesting its importance in risk stratification.

Area of Science:

  • Cardiovascular Medicine
  • Lipidology
  • Hypertension Research

Background:

  • Elevated lipoprotein (a) is an independent risk factor for atherosclerotic cardiovascular disease and calcific aortic valve disease.
  • Limited data exist on the association between elevated lipoprotein (a) and hypertension.
  • Mechanistic links between lipoprotein (a) and hypertension, such as renal impairment or vascular effects, are not well-established.

Purpose of the Study:

  • To review associations between elevated blood pressure and lipoprotein (a).
  • To explore possible causal links between elevated lipoprotein (a) and hypertension.
  • To report the prevalence of elevated lipoprotein (a) in hypertensive patients.

Main Methods:

  • Literature review of studies on lipoprotein (a) and hypertension.
  • Analysis of clinical data from a hypertensive patient cohort.
  • Assessment of lipoprotein (a) levels in at-risk individuals.

Main Results:

  • Approximately 30% of patients in an at-risk, hypertensive cohort exhibited elevated lipoprotein (a) levels.
  • Limited evidence currently supports a direct association between elevated lipoprotein (a) and hypertension.
  • Further research is needed to elucidate mechanistic pathways linking lipoprotein (a) and hypertension.

Conclusions:

  • Elevated lipoprotein (a) may be a significant factor in hypertensive patients.
  • Measurement of lipoprotein (a) could aid in cardiovascular risk stratification for hypertensive individuals.
  • Further investigation into the relationship between lipoprotein (a) and hypertension is warranted.
Abstract

Keywords:
AtherosclerosisCardiovascular riskDyslipidemiaHypertensionLipoprotein (a)Renal functionVascular function

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