Twice neglected? Neglected diseases in neglected populations

Area of Science:

• Clinical Pharmacology
• Drug Development
• Global Health

Background:

• Limited evidence exists for optimal medication use in many populations.
• Neglected tropical diseases (NTDs) disproportionately affect vulnerable groups like children and pregnant women.
• Lack of effective treatments perpetuates cycles of poverty and illness.

Discussion:

• There is a critical need for novel therapies for NTDs in neglected populations.
• Ensuring affordability, availability, and community adaptation of new treatments is paramount.
• The NIH's "4 C's" framework (Consider inclusion, Collect data, Characterize differences, Communicate findings) offers a relevant approach.

Key Insights:

• Dual neglect of diseases and populations requires targeted research.
• Special populations, including children and pregnant women, are often excluded from clinical studies.
• Addressing NTDs in these groups is essential for socioeconomic advancement.

Outlook:

• The British Journal of Clinical Pharmacology calls for high-quality research on NTDs in special populations.
• This initiative aims to reverse the dual neglect and improve health outcomes.
• Further investigation and development of inclusive, adapted treatments are essential.