Vitamin D status is heritable and under environment-dependent selection in the wild

Vitamin D has a well-established role in skeletal health and is increasingly linked to chronic disease and mortality in humans and companion animals. Despite the clear significance of vitamin D for health and obvious implications for fitness under natural conditions, no longitudinal study has tested whether the circulating concentration of vitamin D is under natural selection in the wild. Here, we show that concentrations of dietary-derived vitamin D₂ and endogenously produced vitamin D₃  metabolites are heritable and largely polygenic in a wild population of Soay sheep (Ovis aries). Vitamin D₂  status was positively associated with female adult survival, and vitamin D₃  status predicted female fecundity in particular, good environment years when sheep density and competition for resources was low. Our study provides evidence that vitamin D status has the potential to respond to selection, and also provides new insights into how vitamin D metabolism is associated with fitness in the wild.