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Updated: Oct 10, 2025

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
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Body weight fluctuation is associated with rapid kidney function decline.

Young Su Joo1,2, Ki Heon Nam1,3, Jong Hyun Jhee4

  • 1Institute of Kidney Disease Research, Department of Internal Medicine, College of Medicine, Yonsei University, Seoul, Republic of Korea.

Obesity (Silver Spring, Md.)
|December 10, 2021
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Summary

Significant body weight fluctuations increase the risk of rapid kidney function decline. This study highlights the importance of weight stability for maintaining kidney health in individuals with normal kidney function.

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Area of Science:

  • Nephrology
  • Epidemiology
  • Metabolic Health

Background:

  • Kidney function decline is a significant public health concern.
  • The impact of body weight fluctuations on kidney health is not fully understood.
  • Maintaining stable body weight is crucial for overall health.

Purpose of the Study:

  • To investigate the association between body weight fluctuations and kidney function deterioration.
  • To evaluate the risk of rapid estimated glomerular filtration rate (eGFR) decline in individuals with normal kidney function based on body weight variability.
  • To identify potential modifiable risk factors for kidney disease progression.

Main Methods:

  • Prospective cohort study using data from the Korean Genome and Epidemiology Study.
  • Body weight fluctuations quantified using average successive variability (ASV).
  • Rapid eGFR decline defined as > 3 mL/min/1.73 m²/year, analyzed via linear regression and logistic regression models.

Main Results:

  • Analysis included 6,790 participants with a median follow-up of 11.7 years.
  • Rapid eGFR decline occurred in 13.4% of participants.
  • Higher ASV (body weight fluctuations) was significantly associated with an increased risk of rapid eGFR decline (OR: 1.66 in the highest tertile vs. lowest).

Conclusions:

  • Body weight fluctuations are an independent risk factor for kidney function deterioration.
  • Maintaining stable body weight is recommended for preserving kidney health.
  • Further research should explore interventions to mitigate weight variability and its renal effects.