Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

177
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
177
Biological Influences on Intelligence01:30

Biological Influences on Intelligence

260
Intelligence is often thought to be linked to brain size, but the relationship is more complex than that. While brain size does correlate modestly with some abilities, like verbal skills, the connection is weaker for others, such as spatial reasoning. Other factors, like brain structure, also play crucial roles. For instance, despite Einstein's smaller-than-average brain, his parietal cortex, which is involved in spatial reasoning, was 15% wider, suggesting that neural density might matter...
260
Psychological and Sociocultural Causes of Schizophrenia01:29

Psychological and Sociocultural Causes of Schizophrenia

223
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
223

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The role of the globus pallidus subregions in the schizophrenia spectrum continuum.

Molecular psychiatry·2026
Same author

Evaluation of Oculomotor Function Following Sleep Improvement With Lemborexant in Older Adults With Insomnia.

Human psychopharmacology·2026
Same author

A multilayered model of work outcome in patients with schizophrenia: Examination of the relationships among positive symptoms, cognition, and daily living skills.

Schizophrenia research. Cognition·2026
Same author

Antinephrin, Antipodocin, and Anti-Kirrel1 Autoantibodies in Posttransplant Recurrent FSGS.

Kidney international reports·2026
Same author

Reevaluation of Lateral Ventricular Enlargement in Psychiatry.

Psychiatry and clinical neurosciences·2026
Same author

Development of transdisciplinary approach scale for healthcare professionals.

PCN reports : psychiatry and clinical neurosciences·2026

Related Experiment Video

Updated: Oct 10, 2025

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
09:33

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

28.6K

Association Study Between White Matter Microstructure and Intelligence Decline in Schizophrenia.

Junya Matsumoto1, Kenichiro Miura1, Masaki Fukunaga2

  • 1National Institute of Mental Health, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan.

Clinical EEG and Neuroscience
|December 10, 2021
PubMed
Summary
This summary is machine-generated.

Schizophrenia patients show intelligence decline linked to cognitive impairment. White matter changes were less indicative of this decline than gray matter alterations in this diffusion tensor imaging study.

Keywords:
cognitive declinecognitive impairmentdiffusion tensor imagingschizophreniawhite matter

More Related Videos

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
07:30

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Published on: April 23, 2021

3.2K
Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study
07:30

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Published on: August 18, 2020

6.9K

Related Experiment Videos

Last Updated: Oct 10, 2025

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
09:33

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

28.6K
Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
07:30

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Published on: April 23, 2021

3.2K
Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study
07:30

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Published on: August 18, 2020

6.9K

Area of Science:

  • Neuroimaging
  • Psychiatry
  • Cognitive Neuroscience

Background:

  • Schizophrenia is associated with cognitive impairment, including intelligence decline.
  • Previous studies linked intelligence decline in schizophrenia to altered gray matter and functional connectivity.
  • The role of white matter microstructures in schizophrenia-related intelligence decline remains unclear.

Purpose of the Study:

  • To investigate the relationship between white matter microstructures and intelligence decline in schizophrenia patients.
  • To compare diffusion tensor imaging (DTI) indices between schizophrenia subgroups with different intelligence decline patterns and healthy controls.

Main Methods:

  • Diffusion tensor imaging (DTI) data from 138 schizophrenia patients and 554 healthy controls were analyzed.
  • Schizophrenia patients were categorized into deteriorated, preserved, and compromised IQ subgroups based on intelligence quotient changes.
  • DTI indices were analyzed separately for two MRI scanner groups to account for acquisition differences.

Main Results:

  • Significant differences in DTI indices were observed in specific brain regions between the deteriorated IQ group and healthy controls, regardless of scanner type.
  • Fewer DTI differences were found between the preserved IQ group and healthy controls.
  • No reproducible differences in white matter microstructures were found when directly comparing the deteriorated and preserved IQ groups.

Conclusions:

  • White matter microstructures appear less promising as biomarkers for intelligence decline in schizophrenia compared to gray matter structures and functional connectivity.
  • Gray matter alterations and functional connectivity remain key areas for understanding intelligence decline in schizophrenia.
  • Further research may focus on integrating multimodal imaging data to fully elucidate cognitive impairment mechanisms in schizophrenia.