Shrew submaxillary gland epidermal growth factor: homologous radioreceptor assay and mitogenic activity

A homologous radioreceptor assay was developed to determine the epidermal growth factor (EGF) contents of the shrew submaxillary glands. The results supported previous findings by heterologous radioreceptor assay that this gland in the shrew contained a high level of EGF. This EGF was also found to be a powerful mitogen in two fibroblast cell lines.