Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Potentiometry: Membrane Electrodes

Potentiometry: Membrane Electrodes

Membrane electrodes, also known as p-ion electrodes, use membranes that selectively interact with free analyte ions, generating a potential difference across the membrane. The resulting membrane potential, known as the asymmetry potential, is not zero even when analyte concentrations on both sides of the membrane are equal. The membrane's response is typically not selective to a single analyte but proportional to the concentration of all ions in the sample solution capable of interacting at...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Circulating Tumor Cells Predict Response to the DLL3-Targeting Bispecific Antibody Tarlatamab.

Cancer discovery·2026

Same author

Passivated-electrode insulator-based dielectrophoretic separation of heterogeneous cell mixtures.

Journal of separation science·2020

Same author

N-Phenyl indole derivatives as AT1 antagonists with anti-hypertension activities: Design, synthesis and biological evaluation.

European journal of medicinal chemistry·2016

Same author

Cefradine blocks solar-ultraviolet induced skin inflammation through direct inhibition of T-LAK cell-originated protein kinase.

Oncotarget·2016

Same author

Design, synthesis, cytotoxic activity and molecular docking studies of new 20(S)-sulfonylamidine camptothecin derivatives.

European journal of medicinal chemistry·2016

Same author

Label-free electrochemical immunosensor based on enhanced signal amplification between Au@Pd and CoFe2O4/graphene nanohybrid.

Scientific reports·2016

Same journal

Tunable self-assembling cellular microarray for single-neutrophil vital and suicidal extracellular traps.

Lab on a chip·2026

Same journal

Precise programmable tumor cell subpopulation sorting <i>via</i> an electromagnetic microfluidic platform.

Lab on a chip·2026

Same journal

Bridging dimensions: combining one- and two-photon 3D printing for microfluidic device fabrication.

Lab on a chip·2026

Same journal

Microfluidic rare cell analysis beyond counting: workflow design from enrichment to multi-omics.

Lab on a chip·2026

Same journal

A sperm racetrack to separate sperm by swim speed.

Lab on a chip·2026

Same journal

Controlled encapsulation and droplet size prediction in two-step microfluidic double emulsions.

Lab on a chip·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Oct 10, 2025

Dry Film Photoresist-based Electrochemical Microfluidic Biosensor Platform: Device Fabrication, On-chip Assay Preparation, and System Operation

Dry Film Photoresist-based Electrochemical Microfluidic Biosensor Platform: Device Fabrication, On-chip Assay Preparation, and System Operation

Published on: September 19, 2017

A sample-to-answer electrochemical biosensor system for biomarker detection.

Kruthika Kikkeri¹, Dan Wu², Joel Voldman¹

¹Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA. voldman@mit.edu.

|December 10, 2021

Summary

This summary is machine-generated.

This study introduces an automated electrochemical biosensing platform for rapid biomarker detection. The integrated system streamlines blood collection, sample preparation, and analysis, improving point-of-care diagnostics.

More Related Videos

Fabrication of Electrochemical-DNA Biosensors for the Reagentless Detection of Nucleic Acids, Proteins and Small Molecules

Fabrication of Electrochemical-DNA Biosensors for the Reagentless Detection of Nucleic Acids, Proteins and Small Molecules

Published on: June 1, 2011

Bacterial Detection & Identification Using Electrochemical Sensors

Bacterial Detection & Identification Using Electrochemical Sensors

Published on: April 23, 2013

Related Experiment Videos

Last Updated: Oct 10, 2025

Dry Film Photoresist-based Electrochemical Microfluidic Biosensor Platform: Device Fabrication, On-chip Assay Preparation, and System Operation

Dry Film Photoresist-based Electrochemical Microfluidic Biosensor Platform: Device Fabrication, On-chip Assay Preparation, and System Operation

Published on: September 19, 2017

Fabrication of Electrochemical-DNA Biosensors for the Reagentless Detection of Nucleic Acids, Proteins and Small Molecules

Fabrication of Electrochemical-DNA Biosensors for the Reagentless Detection of Nucleic Acids, Proteins and Small Molecules

Published on: June 1, 2011

Bacterial Detection & Identification Using Electrochemical Sensors

Bacterial Detection & Identification Using Electrochemical Sensors

Published on: April 23, 2013

Area of Science:

Biomedical Engineering
Analytical Chemistry
Point-of-Care Diagnostics

Background:

Centralized laboratory testing for biomarkers leads to delays and increased costs.
Point-of-care (POC) platforms offer rapid biomarker measurement but often neglect sample preparation.
Integrated sample preparation is crucial for efficient POC biomarker analysis.

Purpose of the Study:

To develop a fully integrated, automated sample-to-answer electrochemical biosensing platform.
To combine blood collection, sample preparation, and biomarker assay into a single workflow.
To improve the efficiency and accessibility of biomarker testing.

Main Methods:

A microneedle blood sampling device integrated with membrane-based plasma filtration.
A bead-based electrochemical immunoassay for biomarker detection.
Characterization of plasma separation efficiency and non-specific binding.

Main Results:

Achieved high plasma separation efficiency (>99%) from whole blood.
Demonstrated low non-specific binding with the filtration membrane.
Successfully performed a complete sample-to-answer workflow for biomarker analysis.

Conclusions:

The developed platform provides a fully automated solution for biomarker testing.
This integrated approach enhances the capabilities of point-of-care diagnostic devices.
The system shows promise for improving disease diagnosis and treatment monitoring.